Multiple injections of pegylated liposomal Doxorubicin: pharmacokinetics and therapeutic activity.

@article{Charrois2003MultipleIO,
  title={Multiple injections of pegylated liposomal Doxorubicin: pharmacokinetics and therapeutic activity.},
  author={Gregory J. R. Charrois and Theresa M. Allen},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={306 3},
  pages={1058-67}
}
Effects of multiple injections of liposomal doxorubicin on pharmacokinetics, therapeutic outcome, and toxicity were studied in mice using different dosing schedules and dose intensities. Biodistribution of doxorubicin to the cutaneous tissues of mice (skin and paws) and to orthotopically implanted mammary tumors (4T1) was examined. Weekly intravenous administration of pegylated (STEALTH) liposomal doxorubicin (SL-DXR) at a dose of 9 mg/kg (every week x 4 doses) resulted in accumulation of… CONTINUE READING