Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking.

@article{Stalheim2005MultipleIF,
  title={Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking.},
  author={Lisa Stalheim and Yu Ding and Anuradha Gullapalli and May M. Paing and Breann Louise Wolfe and Dionne R Morris and JoAnn Trejo},
  journal={Molecular pharmacology},
  year={2005},
  volume={67 1},
  pages={78-87}
}
The irreversible proteolytic nature of protease-activated receptor-2 (PAR2) activation suggests that mechanism(s) responsible for termination of receptor signaling are critical determinants of the magnitude and duration of PAR2-elicited cellular responses. Rapid desensitization of activated G-protein-coupled receptors (GPCRs) involves both phosphorylation and binding of arrestins. Arrestins also function as scaffolds and transducers of mitogen-activated protein (MAP) kinase signaling cascades… CONTINUE READING

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