Multiple implications of 3-phosphoinositide-dependent protein kinase 1 in human cancer.


3-phosphoinositide-dependent protein kinase-1 (PDK1) is a central mediator of cellular signaling between phosphoinositide-3 kinase and various intracellular serine/threonine kinases, including protein kinase B, p70 ribosomal S6 kinase, serum and glucocorticoid-inducible kinase, and protein kinase C. PDK1 activates members of the AGC family of protein… (More)
DOI: 10.4331/wjbc.v1.i8.239