Multiple immunostaining methods to detect traumatic axonal injury in the rat fluid-percussion brain injury model.

@article{Hoshino2003MultipleIM,
  title={Multiple immunostaining methods to detect traumatic axonal injury in the rat fluid-percussion brain injury model.},
  author={S. Hoshino and Shiro Kobayashi and Tetsuya Furukawa and Takayuki Asakura and Akira Teramoto},
  journal={Neurologia medico-chirurgica},
  year={2003},
  volume={43 4},
  pages={165-73; discussion 174}
}
Immunohistochemistry using beta-amyloid precursor protein (APP) N-terminus antibodies is routinely used to detect traumatic axonal injury (TAI). The temporal and regional distributions of APP C- and N-terminus immunoreactivity were investigated in rats with experimental brain injury and compared to distribution of neurofilament (NF) immunoreactivity. Male Sprague-Dawley rats underwent right lateral fluid-percussion (FP) brain injury or sham injury. Six FP injury rats and two control rats were… CONTINUE READING
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