Multiple immunoreactive forms of osteocalcin in uremic serum.

@article{Gundberg1986MultipleIF,
  title={Multiple immunoreactive forms of osteocalcin in uremic serum.},
  author={Caren M. Gundberg and Robert S. Weinstein},
  journal={The Journal of clinical investigation},
  year={1986},
  volume={77 6},
  pages={
          1762-7
        }
}
Circulating osteocalcin, which normally reflects the rate of bone formation, is elevated in uremia. In 18 patients receiving maintenance hemodialysis, serum osteocalcin levels were directly related to the bone formation rate (r = 0.88, P less than 0.001), osteoblastic osteoid surface density (r = 0.65, P less than 0.01), and osteoclastic resorptive surface density (r = 0.75, P less than 0.001). Multiple regression analysis showed that osteocalcin levels remained positively correlated with… 
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135 Citations

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Citation Type

Serum osteocalcin in metabolic bone diseases: What is its real significance?
TLDR
Results imply that the antibody used in the assay might recognize not only the entire osteocalcin molecule, but also small epitopes released during the process of bone matrix resorption, which supports the evidence of calcitonin receptors in osteoblastic surfaces.
Clearance of Osteocalcin by Peritoneal Dialysis in Children with End-Stage Renal Disease
TLDR
Osteocalcin is a bone-specific protein whose concentration in blood is a direct reflection of bone turnover, and the efficient clearance of the protein or its metabolic fragments may be a significant factor in the natural history of renal osteodystrophy seen in these patients.
Osteocalcin: an emerging biomarker for bone turnover
TLDR
Different roles of OC are tried to explain, however further studies are required to elucidate the metabolic and hormonal role of OC in human body.
Urinary osteocalcin as a marker of bone metabolism.
TLDR
Three immunoassays developed and evaluated for the detection of various molecular forms of urine OC had unique specificities toward different naturally occurring U-OC fragments and correlated with bone turnover rates assessed by conventional serum markers of bone metabolism.
Multiple osteocalcin fragments in human urine and serum as detected by a midmolecule osteocalcin radioimmunoassay.
TLDR
Urinary OC (uOC) correlated with both skeletal alkaline phosphatase and serum OC, indices of skeletal formation, and determinations of 24-h uOC give integrated values of daily bone turnover rates indicate that uOC is better able to distinguish between normal children with high bone turnover and normal adults.
Serum osteocalcin in Paget's disease of bone: basal concentrations and response to bisphosphonate treatment.
TLDR
It appears that the functions of osteocalcin and AP as well as their initial expression by the osteoblasts are different and that this difference may be important for the quality of bone formed in Paget's disease.
Effect of acute increases in bone matrix degradation on circulating levels of bone‐gla protein
  • L. Riggs, K. Tsai, K. Mann
  • Medicine, Biology
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1986
TLDR
The data suggest that circulating levels of BGP are a measure of bone formation but, at least in subjects with normal renal function, not a measures of bone resorption.
Binding of serum osteocalcin to hydroxyapatite in Paget's disease of bone.
Intact or N-MID osteocalcin assays for assessment of bone formation in hemodialysis patients?
TLDR
The differences between osteocalcin serum levels assessed by intact-OC and NMID-OC methods were statistically significant, however, their correlation was good, so it can be concluded that their clinical application is comparable.
Changes in Serum Osteocalcin Levels in the Follow-Up of Kidney Transplantation
TLDR
The increase in serum osteocalcin levels observed in transplanted patients seems to reflect an increase in the osteoblastic activity, which is not altered by steroid therapy.
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References

SHOWING 1-10 OF 23 REFERENCES
Urinary γ-Carboxyglutamic Acid and Serum Osteocalcin as Bone Markers: Studies in Osteoporosis and Paget’s Disease
Osteocalcin is a major bone matrix protein with high affinity for hydroxyapatite. This property is conferred by several residues of the calcium-binding amino acid γ-carboxyglutamate (Gla), which…
Plasma levels of bone Gla-protein reflect bone formation in patients on chronic maintenance dialysis.
TLDR
Values for BGP indicate that plasma levels of BGP reflect bone formation in uremia and predict underlying bone histology, and correlations between BGP and cellular and non-cellular parameters of bone formation are significant.
Clinical evaluation of bone turnover by serum osteocalcin measurements in a hospital setting.
TLDR
It is demonstrated that serum osteocalcin levels are normal in disorders not involving bone, can be used in a general-hospital setting, where concomitant illnesses are present, and may provide additional information for the clinical evaluation of metabolic bone disease.
SERUM BONE GLA-PROTEIN: A SPECIFIC MARKER FOR BONE FORMATION IN POSTMENOPAUSAL OSTEOPOROSIS
Histological quantitation of aluminum in iliac bone from patients with renal failure.
TLDR
The histochemical staining of aluminum provides a quick and easy method for identifying, localizing, and quantifying aluminum within the bone and may prove to be a useful tool in the study of the mechanisms of metabolic bone disease.
Origin of the vitamin K-dependent bone protein found in plasma and its clearance by kidney and bone.
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TLDR
Plasma BGP was increased in patients with Paget's disease of bone, bone metastases, primary hyperparathyroidism, renal osteodystrophy, and osteopenia and it was observed that patients with liver disease had normal plasma BGP despite increased plasma AP, a reflection of the lack of specificity of AP measurements for bone disease.
Effect of renal function on plasma levels of bone Gla-protein.
TLDR
For normal subjects and patients with mild to moderate renal failure, plasma elevations of BGP reflect increased bone turnover rather than decreased renal filtration.
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