Multiple hypothesis testing in genomics.

  title={Multiple hypothesis testing in genomics.},
  author={Jelle J. Goeman and Aldo Solari},
  journal={Statistics in medicine},
  volume={33 11},
This paper presents an overview of the current state of the art in multiple testing in genomics data from a user's perspective. We describe methods for familywise error control, false discovery rate control and false discovery proportion estimation and confidence, both conceptually and practically, and explain when to use which type of error rate. We elaborate on the assumptions underlying the methods and discuss pitfalls in the interpretation of results. In our discussion, we take into account… CONTINUE READING
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