Multiple hematopoietic growth factors signal through tyrosine phosphorylation.

@article{Isfort1990MultipleHG,
  title={Multiple hematopoietic growth factors signal through tyrosine phosphorylation.},
  author={Robert J. Isfort and James N. Ihle},
  journal={Growth factors},
  year={1990},
  volume={2 2-3},
  pages={213-20}
}
The role of tyrosine phosphorylation in the signal transduction of four hematopoietic colony-stimulating factors (IL-3, IL-4, G-CSF, and GM-CSF) in myeloid cells was investigated. In DA-3 cells, both IL-3 and GM-CSF stimulated, within 10 min, the tyrosine phosphorylation of similar proteins with molecular masses of 70, 56, 51, 42, and 38 kD, as well as two… CONTINUE READING