Multiple genetic variants in telomere pathway genes and breast cancer risk.

@article{Shen2010MultipleGV,
  title={Multiple genetic variants in telomere pathway genes and breast cancer risk.},
  author={Jing Shuang Shen and Marilie Denise Gammon and Hui-Chen Wu and Mary Beth Terry and Qiao Feng Wang and Patrick T Bradshaw and Susan L. Teitelbaum and Alfred I. Neugut and Regina M. Santella},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2010},
  volume={19 1},
  pages={
          219-28
        }
}
PURPOSE To explore the etiologic role of genetic variants in telomere pathway genes and breast cancer risk. METHODS A population-based case-control study, the Long Island Breast Cancer Study Project, was conducted, and 1,067 cases and 1,110 controls were included in the present study. Fifty-two genetic variants of nine telomere-related genes were genotyped. RESULTS Seven single nucleotide polymorphisms (SNP) showed significant case-control differences at the level of P < 0.05. The top three… CONTINUE READING

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