Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E(mu)-v-abl transgenic mice.

@article{Symons2002MultipleGL,
  title={Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E(mu)-v-abl transgenic mice.},
  author={R. C. Andrew Symons and Mark J. Daly and Jane Fridlyand and Terence P. Speed and W. D. Cook and Steven Gerondakis and Alan W. Harris and Simon J Foote},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 17},
  pages={11299-304}
}
There is a great difference in susceptibility to v-abl transgene-induced plasmacytoma between the BALB/cAn and the relatively resistant C57BL/6J mouse strains. We have used the Mapmaker/SURVIVOR algorithm to analyze genome-wide scans on over 800 transgenic F2 hybrid mice, and have mapped at least six loci on chromosomes 2, 4, 11, 17, and 18 that modify tumor-related morbidity. As in human multiple myeloma, males were found to be more prone to plasmacytomagenesis. Different loci influence tumor… CONTINUE READING

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SEER Cancer Statistics Review , 1973 – 1999 ( Natl

L. A. G. Ries, M. P. Eisner, +4 authors B. K. Edwards
2002

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