Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.

@article{Yang2010MultipleGL,
  title={Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.},
  author={Qiong Yang and Anna K{\"o}ttgen and Abbas Dehghan and Albert Vernon Smith and Nicole L. Glazer and M C Chen and Daniel Chasman and Thor Aspelund and Gudny Eir{\'i}ksdott{\'i}r and T. B. Harris and Lenore J. Launer and Michael A. Nalls and Dena G. Hernandez and Dan E Arking and Eric Boerwinkle and Megan L. Grove and Man Li and Wen Hong Linda Kao and Michel B. Chonchol and Talin Haritunians and Guo Li and Thomas Lumley and Bruce M. Psaty and Michael G. Shlipak and S J Hwang and Martin G. Larson and Christopher J. O'Donnell and Ashish Upadhyay and Cornelia M van Duijn and Albert Hofman and Fernando Rivadeneira and Bruno C. Stricker and Andr{\'e} G. Uitterlinden and Guillaume Par{\'e} and Alex N. Parker and Paul M. Ridker and David S Siscovick and Vilmundur Gudnason and Jacqueline C. M. Witteman and Caroline Fox and Josef Coresh},
  journal={Circulation. Cardiovascular genetics},
  year={2010},
  volume={3 6},
  pages={523-30}
}
BACKGROUND Elevated serum urate levels can lead to gout and are associated with cardiovascular risk factors. We performed a genome-wide association study to search for genetic susceptibility loci for serum urate and gout and investigated the causal nature of the associations of serum urate with gout and selected cardiovascular risk factors and coronary heart disease (CHD). METHODS AND RESULTS Meta-analyses of genome-wide association studies (GWAS) were performed in 5 population-based cohorts… CONTINUE READING
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