Multiple genetic backgrounds of the amplified Plasmodium falciparum multidrug resistance (pfmdr1) gene and selective sweep of 184F mutation in Cambodia.

@article{Vinayak2010MultipleGB,
  title={Multiple genetic backgrounds of the amplified Plasmodium falciparum multidrug resistance (pfmdr1) gene and selective sweep of 184F mutation in Cambodia.},
  author={S. Ravi Vinayak and Md Tauqeer Alam and Rithy Sem and Naman Kirit Shah and Agustina Ika Susanti and Pharath Lim and Sinuon Muth and Jason D. Maguire and William Oscar Rogers and Thierry Fandeur and John W. Barnwell and Anan{\'i}as A. Escalante and Chansuda Wongsrichanalai and Frederick Ariey and Steven Richard Meshnick and Venkatachalam Udhayakumar},
  journal={The Journal of infectious diseases},
  year={2010},
  volume={201 10},
  pages={
          1551-60
        }
}
BACKGROUND The emergence of artesunate-mefloquine (AS+MQ)-resistant Plasmodium falciparum in the Thailand-Cambodia region is a major concern for malaria control. Studies indicate that copy number increase and key alleles in the pfmdr1 gene are associated with AS+MQ resistance. In the present study, we investigated evidence for a selective sweep around pfmdr1 because of the spread of adaptive mutation and/or multiple copies of this gene in the P. falciparum population in Cambodia. METHODS We… CONTINUE READING
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