Multiple gene genealogies reveal recent dispersion and hybridization in the human pathogenic fungus Cryptococcus neoformans

@article{Xu2000MultipleGG,
  title={Multiple gene genealogies reveal recent dispersion and hybridization in the human pathogenic fungus Cryptococcus neoformans},
  author={Jianping Xu and Rytas Vilgalys and Thomas G. Mitchell},
  journal={Molecular Ecology},
  year={2000},
  volume={9}
}
Cryptococcus neoformans (= Filobasidiella neoformans) is a significant emerging fungal pathogen of humans. To understand the evolution of this pathogen, 34 strains were obtained from various locations around the world and fragments of four genes were sequenced from each. These strains represented all three varieties and five serotypes. The four sequenced genes are: (i) the mitochondrial large ribosomal subunit RNA; (ii) the internal transcribed spacer region of the nuclear rRNA, including ITS1… 

Mitochondrial Genome Polymorphisms in the Human Pathogenic Fungus Cryptococcus neoformans

A dynamic evolution of mitochondrial genomes in this important human fungal pathogen is revealed and the combined mitogenome exon-based phylogeny and intron distributions suggested that clades VNI, VNII and VNB could be further divided into sub-clades.

Recent evolution of the human pathogen Cryptococcus neoformans by intervarietal transfer of a 14-gene fragment.

Data indicate that DNA exchange between closely related sympatric varieties or species may be a recurrent theme in the evolution of fungal species, and suggests that although evolutionary divergence is the primary force driving speciation, rare introgression events also play a potentially important role.

Population genomics of Cryptococcus neoformans var. grubii reveals new biogeographic relationships and finely maps hybridization

While the three major lineages of C. grubii are well separated, recombination between the lineages has occurred, notably resulting in hybrid isolates with segmented ancestry across the genome, which provides evidence of substantial population structure.

Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level

Phylogenetic and population genomic analyses of isolates from Brazil reveal that the previously “African” VNB lineage occurs naturally in the South American environment, which suggests migration of the V NB lineage between Africa and South America prior to its diversification.

Chromosomal Rearrangements between Serotype A and D Strains in Cryptococcus neoformans

It is identified that overall, rearranged regions had recombination frequencies about half of those around syntenic regions, and the implications of these results on the genome structure, ecology, and evolution of C. neoformans are discussed.

Multiple gene genealogical analyses suggest divergence and recent clonal dispersal in the opportunistic human pathogen Candida guilliermondii.

DNA fragments were sequenced from five genes for each of 37 strains collected from Canada, China, the Philippines and Tanzania, revealing significant divergence and clonal dispersal in this important pathogenic yeast complex.

Correction: Genetic Diversity of the Cryptococcus Species Complex Suggests that Cryptococcus gattii Deserves to Have Varieties

The genetic variation found among all of these haploid monophyletic lineages in the Cryptococcus species complex indicates that they warrant varietal status.

Genetic Analysis of a Hybrid Cross between Cryptococcus neoformans and Cryptococcus deneoformans

There is mitotic recombination during the production of the hybrids, that there are genetic incompatibilities between C. neoformans and C. deneoformans, and that differences between the two species in virulencerelated traits are controlled by multiple quantitative genetic loci.

Comparative Gene Genealogies Indicate that Two Clonal Lineages of Cryptococcus gattii in British Columbia Resemble Strains from Other Geographical Areas

The results indicate that the C. gattii population in B.C. comprises at least two divergent lineages, corresponding to previously identified VGI and VGII molecular types.
...

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