Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival

@article{Koshimizu2009MultipleFO,
  title={Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival},
  author={Hisatsugu Koshimizu and Kazuyuki Kiyosue and Tomoko Hara and Shunsuke Hazama and Shingo Suzuki and Koichi Uegaki and Guhan Nagappan and Eugene Zaitsev and Takatsugu Hirokawa and Yoshiro Tatsu and Akihiko Ogura and Bai Lu and Masami Kojima},
  journal={Molecular Brain},
  year={2009},
  volume={2},
  pages={27 - 27}
}
Proneurotrophins and mature neurotrophins elicit opposite effects via the p75 neurotrophin receptor (p75NTR) and Trk tyrosine kinase receptors, respectively; however the molecular roles of proneurotrophins in the CNS are not fully understood. Based on two rare single nucleotide polymorphisms (SNPs) of the human brain-derived neurotrophic factor (BDNF) gene, we generated R125M-, R127L- and R125M/R127L-BDNF, which have amino acid substitution(s) near the cleavage site between the pro- and mature… CONTINUE READING

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