Multiple functions of cation-chloride cotransporters in the fish retina.

@article{Dmitriev2007MultipleFO,
  title={Multiple functions of cation-chloride cotransporters in the fish retina.},
  author={Andrey V. Dmitriev and Nina A Dmitrieva and Kent T. Keyser and Stuart C. Mangel},
  journal={Visual neuroscience},
  year={2007},
  volume={24 4},
  pages={635-45}
}
A GABA- or glycine-induced increase in Cl(-) permeability can produce either a depolarization or hyperpolarization, depending on the Cl(-) equilibrium potential. It has been shown that retinal neurons express the chloride cotransporters, Na-K-2Cl (NKCC) and K-Cl (KCC), the primary molecular mechanisms that control the intracellular Cl(-) concentration. We thus studied (1) the localization of these cotransporters in the fish retina, and (2) how suppression of cotransporter activity in the fish… CONTINUE READING