Multiple functions of an evolutionarily conserved RNA binding domain.

  title={Multiple functions of an evolutionarily conserved RNA binding domain.},
  author={J. Vilardell and Simon J. Yu and J. R. Warner},
  journal={Molecular cell},
  volume={5 4},
Ribosomal protein L30 of Saccharomyces cerevisiae binds to a distinct RNA structure to inhibit the splicing and the translation of its own transcript. Remarkably, the ortholog of L30 from the archaeon Sulfolobus acidocaldarius binds specifically to the same RNA fragment and inhibits splicing both in vitro and in vivo. Indeed, expression of Sulfolobus L30 in yeast severely reduces growth by limiting production of the endogenous L30. This conservation of binding specificity implies that the… CONTINUE READING

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