Multiple functions of Cerberus cooperate to induce heart downstream of Nodal.

@article{Foley2007MultipleFO,
  title={Multiple functions of Cerberus cooperate to induce heart downstream of Nodal.},
  author={Ann C Foley and Oksana Korol and Anjuli M. Timmer and M. Mercola},
  journal={Developmental biology},
  year={2007},
  volume={303 1},
  pages={57-65}
}
The TGFbeta family member Nodal has been implicated in heart induction through misexpression of a dominant negative version of the type I Nodal receptor (Alk4) and targeted deletion of the co-receptor Cripto in murine ESCs and mouse embryos; however, whether Nodal acts directly or indirectly to induce heart tissue or interacts with other signaling molecules or pathways remained unclear. Here we present Xenopus embryological studies demonstrating an unforeseen role for the DAN family protein… CONTINUE READING
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