Multiple functions for the N-terminal region of Msh6

@inproceedings{Clark2007MultipleFF,
  title={Multiple functions for the N-terminal region of Msh6},
  author={Alan B. Clark and Leesa J. Deterding and Kenneth B. Tomer and T. A. Kunkel},
  booktitle={Nucleic acids research},
  year={2007}
}
The eukaryotic mismatch repair protein Msh6 shares five domains in common with other MutS members. However, it also contains several hundred additional residues at its N-terminus. A few of these residues bind to PCNA, but the functions of the other amino acids in the N-terminal region (NTR) are unknown. Here we demonstrate that the Msh6 NTR binds to duplex DNA in a salt-sensitive, mismatch-independent manner. Partial proteolysis, DNA affinity chromatography and mass spectrometry identified a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

DNA mismatch repair: molecular mechanism, cancer, and ageing.

Mechanisms of ageing and development • 2008
View 2 Excerpts

References

Publications referenced by this paper.

Similar Papers

Loading similar papers…