Multiple functions for the N-terminal region of Msh6

  title={Multiple functions for the N-terminal region of Msh6},
  author={Alan B. Clark and Leesa J. Deterding and Kenneth B. Tomer and T. A. Kunkel},
  booktitle={Nucleic acids research},
The eukaryotic mismatch repair protein Msh6 shares five domains in common with other MutS members. However, it also contains several hundred additional residues at its N-terminus. A few of these residues bind to PCNA, but the functions of the other amino acids in the N-terminal region (NTR) are unknown. Here we demonstrate that the Msh6 NTR binds to duplex DNA in a salt-sensitive, mismatch-independent manner. Partial proteolysis, DNA affinity chromatography and mass spectrometry identified a… CONTINUE READING


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