Multiple functional domains of human U2 small nuclear RNA: strengthening conserved stem I can block splicing.

@article{Wu1992MultipleFD,
  title={Multiple functional domains of human U2 small nuclear RNA: strengthening conserved stem I can block splicing.},
  author={June K. Wu and James L Manley},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 12},
  pages={
          5464-73
        }
}
We showed previously that a branch site mutation in simian virus 40 early pre-mRNA that prevented small t antigen mRNA splicing could be efficiently suppressed by a compensatory mutation in a coexpressed U2 small nuclear (sn) RNA gene. We have now generated second-site mutations in this suppressor gene to investigate regions of U2 RNA required for function. A number of mutations in a putative stem at the 5' end of the molecule inhibited splicing, indicating that bases in this region are… CONTINUE READING
Highly Cited
This paper has 22 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations