Multiple functional domains and complexes of the two nonstructural proteins of human respiratory syncytial virus contribute to interferon suppression and cellular location.

@article{Swedan2011MultipleFD,
  title={Multiple functional domains and complexes of the two nonstructural proteins of human respiratory syncytial virus contribute to interferon suppression and cellular location.},
  author={Samer Swedan and Joel Andrews and Tanmay Majumdar and Alla Musiyenko and Sasmita Barik},
  journal={Journal of virology},
  year={2011},
  volume={85 19},
  pages={
          10090-100
        }
}
Human respiratory syncytial virus (RSV), a major cause of severe respiratory diseases, efficiently suppresses cellular innate immunity, represented by type I interferon (IFN), using its two unique nonstructural proteins, NS1 and NS2. In a search for their mechanism, NS1 was previously shown to decrease levels of TRAF3 and IKKε, whereas NS2 interacted with RIG-I and decreased TRAF3 and STAT2. Here, we report on the interaction, cellular localization, and functional domains of these two proteins… CONTINUE READING

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