Multiple founder effects and geographical clustering of BRCA1 and BRCA2 families in Finland

@article{Sarantaus2000MultipleFE,
  title={Multiple founder effects and geographical clustering of BRCA1 and BRCA2 families in Finland},
  author={Laura Sarantaus and Pia Huusko and Hannaleena Eerola and Virpi Launonen and Paula Vehmanen and Katrin Rapakko and Elizabeth Gillanders and Kirsi Syrj{\"a}koski and Tommi Kainu and Pia Vahteristo and Ralf Krahe and Kati P{\"a}{\"a}kk{\"o}nen and Jaana M. Hartikainen and Carl Blomqvist and Tuija L{\"o}pp{\"o}nen and Kaija A Holli and Markku Ryyn{\"a}nen and Ralf B{\"u}tzow and {\AA}ke Borg and Brita Wasteson Arver and Eva E Holmberg and Arto J Mannermaa and Juha Kere and Olli-Pekka Kallioniemi and Robert Winqvist and Heli Nevanlinna},
  journal={European Journal of Human Genetics},
  year={2000},
  volume={8},
  pages={757-763}
}
In the Finnish breast and ovarian cancer families six BRCA1 and five BRCA2 mutations have been found recurrently. Some of these recurrent mutations have also been seen elsewhere in the world, while others are exclusively of Finnish origin. A haplotype analysis of 26 Finnish families carrying a BRCA1 mutation and 20 families with a BRCA2 mutation indicated that the carriers of each recurrent mutation have common ancestors. The common ancestors were estimated to trace back to 7–36 generations… CONTINUE READING