Multiple founder effects and geographical clustering of BRCA1 and BRCA2 families in Finland


In the Finnish breast and ovarian cancer families six BRCA1 and five BRCA2 mutations have been found recurrently. Some of these recurrent mutations have also been seen elsewhere in the world, while others are exclusively of Finnish origin. A haplotype analysis of 26 Finnish families carrying a BRCA1 mutation and 20 families with a BRCA2 mutation indicated… (More)
DOI: 10.1038/sj.ejhg.5200529


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