Multiple factors insulate Msh2-Msh6 mismatch repair activity from defects in Msh2 domain I.

@article{kumar2011MultipleFI,
  title={Multiple factors insulate Msh2-Msh6 mismatch repair activity from defects in Msh2 domain I.},
  author={C. Simil kumar and Sarah C Piacente and Justin G Sibert and Andrew R Bukata and Jaime O'Connor and Eric Alani and Jennifer A Surtees},
  journal={Journal of molecular biology},
  year={2011},
  volume={411 4},
  pages={765-80}
}
DNA mismatch repair (MMR) is a highly conserved mutation avoidance mechanism that corrects DNA polymerase misincorporation errors. In initial steps in MMR, Msh2-Msh6 binds mispairs and small insertion/deletion loops, and Msh2-Msh3 binds larger insertion/deletion loops. The msh2Δ1 mutation, which deletes the conserved DNA-binding domain I of Msh2, does not dramatically affect Msh2-Msh6-dependent repair. In contrast, msh2Δ1 mutants show strong defects in Msh2-Msh3 functions. Interestingly… CONTINUE READING