Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies

@article{Cossart2005MultipleFO,
  title={Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies},
  author={Rosa Cossart and Christophe Bernard and Yehezkel Ben-Ari},
  journal={Trends in Neurosciences},
  year={2005},
  volume={28},
  pages={108-115}
}
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The purpose of this review is to discuss recent findings highlighting the significance of GABAA receptor heterogeneity for the concept of E/I balance and its relevance for epilepsy, and to address the following issues: role for tonic inhibition, mediated by extrasynaptic GAB AA receptors, for controlling neuronal excitability; significance of chloride ion transport for maintenance of the E-I balance in adult brain; and molecular mechanisms underlying GabAA receptor regulation that are important for homoeostatic plasticity.
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