• DOI:10.1016/j.tins.2004.11.011
Corpus ID: 1424286

Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies

@article{Cossart2005MultipleFO,
  title={Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies},
  author={R. Cossart and C. Bernard and Y. Ben-Ari},
  journal={Trends in Neurosciences},
  year={2005},
  volume={28},
  pages={108-115}
}

R. Cossart, C. Bernard, Y. Ben-Ari

Published 2005

Biology, Medicine

Trends in Neurosciences

Because blocking GABAergic neurotransmission in control tissue generates seizures and because GABA boosters control epilepsy in many patients, studies on epilepsies have been dominated by the axiom that seizures are generated by a failure of GABA-mediated inhibition. However, GABAergic interneurons and synapses are heterogeneous and have many roles that go beyond the straightforward concept of "inhibition of the target". Operation of such a diversified system cannot be ascribed to a single… CONTINUE READING

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