Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies

  title={Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies},
  author={R. Cossart and C. Bernard and Y. Ben-Ari},
  journal={Trends in Neurosciences},
  • R. Cossart, C. Bernard, Y. Ben-Ari
  • Published 2005
  • Biology, Medicine
  • Trends in Neurosciences
  • Because blocking GABAergic neurotransmission in control tissue generates seizures and because GABA boosters control epilepsy in many patients, studies on epilepsies have been dominated by the axiom that seizures are generated by a failure of GABA-mediated inhibition. However, GABAergic interneurons and synapses are heterogeneous and have many roles that go beyond the straightforward concept of "inhibition of the target". Operation of such a diversified system cannot be ascribed to a single… CONTINUE READING
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