Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity.

@article{Claing2000MultipleEP,
  title={Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity.},
  author={Audrey Claing and Stephen J. Perry and M Achiriloaie and Julia K. L. Walker and Joseph P Albanesi and Robert J Lefkowitz and Richard T Premont},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 3},
  pages={
          1119-24
        }
}
Recently, we identified a GTPase-activating protein for the ADP ribosylation factor family of small GTP-binding proteins that we call GIT1. This protein initially was identified as an interacting partner for the G protein-coupled receptor kinases, and its overexpression was found to affect signaling and internalization of the prototypical beta(2)-adrenergic receptor. Here, we report that GIT1 overexpression regulates internalization of numerous, but not all, G protein-coupled receptors. The… CONTINUE READING

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Effect of GIT1 overexpression on transferrin uptake

  • S. S. Yu, R. J. Lefkowitz, W. P. Hausdorff
  • J. Biol
  • 1993
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