Multiple endocrine neoplasias type 2B and RET proto-oncogene

  title={Multiple endocrine neoplasias type 2B and RET proto-oncogene},
  author={Giuseppe Martucciello and Margherita Lerone and Lara Bricco and Gian Paolo Tonini and Laura L. Lombardi and Carmine G Del Rossi and S Bernasconi},
  booktitle={Italian journal of pediatrics},
Multiple Endocrine Neoplasia type 2B (MEN 2B) is an autosomal dominant complex oncologic neurocristopathy including medullary thyroid carcinoma, pheochromocytoma, gastrointestinal disorders, marphanoid face, and mucosal multiple ganglioneuromas. Medullary thyroid carcinoma is the major cause of mortality in MEN 2B syndrome, and it often appears during the first years of life. RET proto-oncogene germline activating mutations are causative for MEN 2B. The 95% of MEN 2B patients are associated… CONTINUE READING


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