Multiple endocrine neoplasia type I variants and phenocopies: more than a nosological issue?

@article{Falchetti2009MultipleEN,
  title={Multiple endocrine neoplasia type I variants and phenocopies: more than a nosological issue?},
  author={Alberto Falchetti and Maria Luisa Brandi},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2009},
  volume={94 5},
  pages={1518-20}
}
Multiple endocrine neoplasia type I (MEN1) is a rare hereditary tumor syndrome, transmitted as an autosomal dominant trait, caused by mutations in the MEN1 gene encoding menin, a 610-amino-acid tumor suppressor protein, widely expressed in both endocrine and nonendocrine tissues (1). In fact, MEN1 patients display a large spectrum of benign and malignant endocrine lesions, including hyperparathyroidism as well as pituitary and enteropancreatic tumors, and also nonendocrine tumors (e.g. lipomas… CONTINUE READING

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