Multiple endocrine neoplasia type 2B with a RET proto-oncogene A883F mutation displays a more indolent form of medullary thyroid carcinoma compared with a RET M918T mutation.

@article{Jasim2011MultipleEN,
  title={Multiple endocrine neoplasia type 2B with a RET proto-oncogene A883F mutation displays a more indolent form of medullary thyroid carcinoma compared with a RET M918T mutation.},
  author={Sina Jasim and Anita K. Ying and Steven G. Waguespack and Thereasa A. Rich and Elizabeth Gardner Grubbs and Camilo Jim{\'e}nez and Mimi I-Nan Hu and G. J. Cote and Mouhammed Amir Habra},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2011},
  volume={21 2},
  pages={189-92}
}
BACKGROUND Most cases of multiple endocrine neoplasia type 2B (MEN-2B) are attributable to a germline methionine to threonine mutation at codon 918 (M918T) of the RET proto-oncogene; very few cases of a germline alanine to phenylalanine mutation at codon 883 (A883F) are reported without a clear description of the clinical course. Nevertheless, RET-A883F is currently considered to be among the highest risk mutations, and prophylactic thyroidectomy is recommended as early as 6 months of life… CONTINUE READING
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