Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia

@inproceedings{Harding2009MultipleEN,
  title={Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia},
  author={Brian Harding and Manuel Carlos Lemos and Anita A. C. Reed and Gerard V. Walls and Jeshmi Jeyabalan and Michael R. Bowl and Hilda Tateossian and Nicky Sullivan and Tertius Hough and W. D. Fraser and Olaf Ansorge and Michael T. Cheeseman and Rajesh V Thakker},
  booktitle={Endocrine-related cancer},
  year={2009}
}
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours. The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by deleting Men1 exons 1 and 2 and investigated… CONTINUE READING