Multiple endocrine neoplasia type 1 associated with breast cancer: A case report and review of the literature

@article{Jeong2014MultipleEN,
  title={Multiple endocrine neoplasia type 1 associated with breast cancer: A case report and review of the literature},
  author={Young Ju Jeong and Hoon Kyu Oh and Jin gu Bong},
  journal={Oncology Letters},
  year={2014},
  volume={8},
  pages={230 - 234}
}
Multiple endocrine neoplasia type 1 (MEN1) is a cancer predisposition syndrome that includes a combination of endocrine and non-endocrine tumors. The present study reports a rare case of MEN1 associated with breast cancer with the MEN1 gene mutation. A 45-year-old female was diagnosed with breast cancer subsequent to presenting with a right breast mass. Pre-operative radiological studies indicated right breast cancer with a suspicious metastatic nodule of the lung. Further studies demonstrated… Expand
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TLDR
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TLDR
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TLDR
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TLDR
This is the first reported case of ectopic GHRH in a paediatric setting leading to gigantism in a patient with MEN1, and it is suggested that a chest X-ray and an abdominal ultrasound checking the adrenal glands and the pancreas should be included in the routine work-up of newly diagnosed acromegaly patients. Expand
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References

SHOWING 1-10 OF 41 REFERENCES
Primary hyperparathyroidism associatiated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene.
TLDR
An alteration of the MEN1 gene and/or another tumor suppressor gene located at the MEN 1 locus on chromosome 11q13 may be responsible for the development of parathyroid adenoma and breast cancer in a 44-year-old woman suggesting that the clinical spectrum of MEN1 might include breast cancer. Expand
Association of parathyroid tumors in multiple endocrine neoplasia type 1 with loss of alleles on chromosome 11.
TLDR
It is concluded that a single inherited locus on chromosome 11, band q13, causesMEN-1 and that the monoclonal development of parathyroid and pancreatic tumors in patients with MEN-1 involves similar allelic deletions on chromosomes 11. Expand
Genetic and Clinical Features of Multiple Endocrine Neoplasia Types 1 and 2
TLDR
A strong genotype-phenotype correlation has been observed and a specific RET mutation may be responsible for a more or less aggressive clinical course in patients with advanced MTC. Expand
Variable clinical expression in patients with a germline MEN1 disease gene mutation: clues to a genotype–phenotype correlation
TLDR
Reports on exceptional clinical presentations of multiple endocrine neoplasia type 1 are discussed, which may provide more insight into the pathogenesis of this disorder and offer clues for a possible genotype–phenotype correlation. Expand
Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene
TLDR
The clinical aspects and molecular genetics of MEN1 are reviewed together with the reported 1,336 mutations, which are likely to disrupt the interactions of menin with other proteins and thereby alter critical events in cell cycle regulation and proliferation. Expand
Genotype-phenotype analysis in multiple endocrine neoplasia type 1.
TLDR
The type and location of MEN1 mutations may be associated with the phenotypic expression of specific tumors, and such information may assist in the genetic counseling and surveillance of at-risk patients. Expand
Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders.
TLDR
A total of 84 families and/or isolated patients with either MEN1 or MEN1-related inherited endocrine tumors were screened for MEN1 germ-line mutations, by heteroduplex and sequence analysis of the MEN1 gene-coding region and untranslated exon 1, and 52 distinct mutations were characterized. Expand
Guidelines for diagnosis and therapy of MEN type 1 and type 2.
TLDR
The specific RET codon mutation correlates with the MEN2 syndromic variant, the age of onset of M TC, and the aggressiveness of MTC; consequently, that mutation should guide major management decisions, such as whether and when to perform thyroidectomy. Expand
CONSENSUS: Guidelines for Diagnosis and Therapy of MEN Type 1 and Type 2
TLDR
The specific RET codon mutation correlates with the MEN2 syndromic variant, the age of onset of M TC, and the aggressiveness of MTC; consequently, that mutation should guide major management decisions, such as whether and when to perform thyroidectomy. Expand
Alterations of the MEN1 gene in sporadic parathyroid tumors.
TLDR
The findings of inactivating mutation in tumors with LOH at 11q13 confirm the role of the MEN1 tumor suppressor gene in a subset of sporadic parathyroid tumors. Expand
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3
4
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