Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.

@article{Zhao2004MultipleER,
  title={Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.},
  author={Xiangshan Zhao and Lixia Gan and Haiyun Pan and Donghui Kan and Michael W. Majeski and Stephen A. Adam and Terry G. Unterman},
  journal={The Biochemical journal},
  year={2004},
  volume={378 Pt 3},
  pages={839-49}
}
FOXO1, a Forkhead transcription factor, is an important target of insulin and growth factor action. Phosphorylation of Thr-24, Ser-256 and Ser-319 promotes nuclear exclusion of FOXO1, yet the mechanisms regulating nuclear/cytoplasmic shuttling of FOXO1 are poorly understood. Previous studies have identified an NLS (nuclear localization signal) in the C-terminal basic region of the DBD (DNA-binding domain), and a leucine-rich, leptomycin-B sensitive NES (nuclear export signal) located further… CONTINUE READING

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Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

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