Multiple effects of tetrahydroaminoacridine on the cholinergic system: biochemical and behavioural aspects.

@article{Adem1990MultipleEO,
  title={Multiple effects of tetrahydroaminoacridine on the cholinergic system: biochemical and behavioural aspects.},
  author={Abdu Adem and Alaa Kareem Mohammed and Bengt Winblad},
  journal={Journal of neural transmission. Parkinson's disease and dementia section},
  year={1990},
  volume={2 2},
  pages={
          113-28
        }
}
9-Amino-1,2,3,4-tetrahydroaminoacridine (THA) in combination with lecithin has been reported to improve the memory of Alzheimer's disease patients. We have examined some properties of THA in vitro and in vivo so as to define some of the mechanism(s) by which THA might produce its therapeutic effects. In vitro, THA was more potent at inhibiting human plasma cholinesterase (IC50 = 0.03 microM) than human erythrocyte acetylcholinesterase (IC50 = 0.3 microM) and rat brain acetylcholinesterase (IC50… CONTINUE READING

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