Multiple effects of genetic background on variegated transgene expression in mice.

  title={Multiple effects of genetic background on variegated transgene expression in mice.},
  author={Margaret L. Opsahl and Margaret McClenaghan and Anthea J. Springbett and Sarah Reid and Richard Lathe and Alan Colman and Christopher Bruce Alexander Whitelaw},
  volume={160 3},
BLG/7 transgenic mice express an ovine beta-lactoglobulin transgene during lactation. Unusually, transgene expression levels in milk differ between siblings. This variable expression is due to variegated transgene expression in the mammary gland and is reminiscent of position-effect variegation. The BLG/7 line was created and maintained on a mixed CBA x C57BL/6 background. We have investigated the effect on transgene expression of backcrossing for 13 generations into these backgrounds. Variable… CONTINUE READING

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Publications referenced by this paper.

Activation of themodifier Su ( var ) 3 - 9 encode centromere - associated proteins which complex with the heterochromatin component M 31

  • N. D. Allen, M. L. Norris, M. A. Surani
  • EMBO J .
  • 2000

Vagaries of variegating trans - mechanism exists in mammals to selectively silence foreign genes

  • A. J. M. Matzke, A. J. Clark
  • Bioessays
  • 1996

The Aequorea victoria green fluorescent protein can be used as a reporter in live zebra - of Drosophila

  • D. S. Hogness, S. Lin, N. Hopkins
  • Proc . Natl . Acad . Sci . USA
  • 1995

Molecular mechanisms of cellular determination : 1996 Variegated transgene expression in mouse mammary their relation to chromatin structure and parental imprinting

  • K. W. Dobie, M. Lee, J. A. Fantes, E. Graham, A. J. Clark, P. B. Singh
  • Proc . Cell Sci .
  • 1994

Epigenetic Control of expression and methylation of a hepatitis B virus repeat - induced gene silencing ( RIGS ) in Arabidopsis . Plant Mol . transgene by strain - specific modifiers

  • J. Schweizer, P. Valenze-Schaerly, +4 authors E. R. Signer
  • DNA Cell Biol .
  • 1993

Position independent expression of the ovine hCD 2 locus control region / Ig enhancer regulatory element .  - lactoglobulin gene in mice

  • S. Henikoff, M. Kearns, +8 authors J. P. Simons
  • Biochem . J .
  • 1992

LITERATURE CITED Cellular mosaicism in the methylation and expression of hemizy - gous loci in the mouse

  • L. Aagaard, G. Laible, +6 authors K. Monkhorst
  • Genes Dev .
  • 1989

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