Multiple effects of ethanol on cardiac adenylate cyclase.


We characterized the effects of ethanol on the activators of adenylate cyclase complex that act through the receptor site, the stimulatory guanine nucleotide-binding regulatory protein (Gs), or the catalytic unit. Ethanol had no effect on adenylate cyclase activity stimulated by Mn2+, a selective activator of the catalytic unit, whereas high concentrations… (More)