Multiple effects of copper on NMDA receptor currents.

@article{Marchetti2014MultipleEO,
  title={Multiple effects of copper on NMDA receptor currents.},
  author={Carla Marchetti and Irena Baranowska-Bosiacka and Paola Gavazzo},
  journal={Brain research},
  year={2014},
  volume={1542},
  pages={20-31}
}
Copper (Cu) is an essential metal present in the human brain and released from synaptic vesicles following neuronal depolarization. Cu is known to reduce the NMDA receptor (NR) current with IC50≈20 µM. We have studied the effect of Cu on the NR current in cultured neonatal rat cerebellum granule cells (CGC) and in transiently transfected HEK293 cells (HEK), expressing either GluN1/GLUN2A or GluN1/GluN2B receptors. In CGCs, Cu causes a potentiation of the NR current at concentrations <30 µM… CONTINUE READING
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