Multiple effects of codon usage optimization on expression and immunogenicity of DNA candidate vaccines encoding the human immunodeficiency virus type 1 Gag protein.

@article{Deml2001MultipleEO,
  title={Multiple effects of codon usage optimization on expression and immunogenicity of DNA candidate vaccines encoding the human immunodeficiency virus type 1 Gag protein.},
  author={Ludwig Deml and Alexandra Bojak and Susan E Steck and Marcus Graf and Jens Wild and R. Schirmbeck and H. -R. Wolf and Ralf Wagner},
  journal={Journal of virology},
  year={2001},
  volume={75 22},
  pages={10991-1001}
}
We have analyzed the influence of codon usage modifications on the expression levels and immunogenicity of DNA vaccines, encoding the human immunodeficiency virus type 1 (HIV-1) group-specific antigen (Gag). In the presence of Rev, an expression vector containing the wild-type (wt) gag gene flanked by essential cis-acting sites such as the 5'-untranslated… CONTINUE READING