Multiple drug resistant, tumorigenic stem-like cells in oral cancer.

Abstract

An in vitro cell line model was established to exemplify tumor stem cell concept in oral cancer. We were able to identify CD147 expressing fractions in SCC172 OSCC cell line with differing Hoechst dye efflux activity and DNA content. In vivo tumorigenic assay revealed three fractions enriched with stem-like cells capable of undergoing mesenchymal transition… (More)
DOI: 10.1016/j.canlet.2013.06.011

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