Multiple drug resistance gene expression in human renal cell cancer is associated with the histologic subtype.

@article{Rochlitz1992MultipleDR,
  title={Multiple drug resistance gene expression in human renal cell cancer is associated with the histologic subtype.},
  author={Christoph Rochlitz and Hartmut Lobeck and Stephan Peter and J{\"u}rgen Reuter and B. Mohr and Eric de Kant and Dieter Huhn and Richard Herrmann},
  journal={Cancer},
  year={1992},
  volume={69 12},
  pages={
          2993-8
        }
}
Overexpression of p170 glycoprotein, the product of the multiple drug resistance (mdr) gene, has been associated with resistance to various cytotoxic drugs used in the treatment of human neoplasms. Normal renal epithelial cells express p170 as a function of their secretory capacity. Because renal cell carcinomas (RCC) respond poorly to chemotherapeutic regimens, p170 expression was studied in primary RCC. Such expression was measured in 40 human RCC and normal kidney tissues using… CONTINUE READING
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