Multiple dose pharmacokinetics of quetiapine and some of its metabolites in Chinese suffering from schizophrenia.

@article{Li2004MultipleDP,
  title={Multiple dose pharmacokinetics of quetiapine and some of its metabolites in Chinese suffering from schizophrenia.},
  author={Kun-yan Li and Xin Li and Ze-neng Cheng and Wen-xing Peng and Bikui Zhang and Huan-De Li},
  journal={Acta pharmacologica Sinica},
  year={2004},
  volume={25 3},
  pages={
          390-4
        }
}
AIM To study the multiple dose pharmacokinetics of quetiapine and its sulfoxide-, 7-hydroxy-, 7-hydroxy-N-dealkyl-metabolites in Chinese suffering from schizophrenia. METHODS Twenty-one patients (11 females and 10 males) were given quetiapine twice daily to control the symptoms. After the dose reached 200 mg twice daily, blood were sampled to study the pharmacokinetics. The plasma concentrations of quetiapine and its metabolites were assayed by HPLC-MS. RESULTS The main pharmacokinetic… CONTINUE READING