Multiple dose pharmacokinetics of ketoconazole and their effects on antipyrine kinetics in man.

@article{Daneshmend1983MultipleDP,
  title={Multiple dose pharmacokinetics of ketoconazole and their effects on antipyrine kinetics in man.},
  author={T. K. Daneshmend and D. W. Warnock and M. D. Ene and Elizabeth I M Johnson and Gabrielle Parker and Malcolm D Richardson and Charles J. Roberts},
  journal={The Journal of antimicrobial chemotherapy},
  year={1983},
  volume={12 2},
  pages={
          185-8
        }
}
Ketoconazole 200 mg was given twice daily for five days to eight subjects. The serum pharmacokinetics were examined with the first dose on day 1 and with the ninth dose on day 5. The serum half life of ketoconazole was 74.8 +/- 13.9 min (mean +/- S.D.) on day 1, and 155.9 +/- 32.7 min on day 5. On day 1 the area under the serum concentration time curve was 626.9 +/- 230.1 mg/l.min, and 1441 +/- 897.3 mg/l.min on day 5. Antipyrine kinetics were determined before and after the course of… CONTINUE READING

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