Multiple-dose efficacy comparison of the two topical carbonic anhydrase inhibitors sezolamide and MK-927.

@article{Bron1991MultipledoseEC,
  title={Multiple-dose efficacy comparison of the two topical carbonic anhydrase inhibitors sezolamide and MK-927.},
  author={Anthony John Bron and Erik A. Lippa and Frans P Gunning and C. Benichou and P. Lesure and Daniel Sirbat and James Royer and Jacques Flament and Coleen M Clineschmidt and Deborah Panebianco},
  journal={Archives of ophthalmology},
  year={1991},
  volume={109 1},
  pages={50-3}
}
The multiple-dose twice-daily efficacy of the topical carbonic anhydrase inhibitor MK-927, a racemic compound, was compared with that of its pharmacologically more active S-enantiomer in a four-center, double-masked, randomized, placebo-controlled, parallel study of 1.8% sezolamide hydrochloride (MK-417), 2% MK-927, and placebo, given twice daily to 48… CONTINUE READING