Multiple dopamine D4 receptor variants in the human population

@article{Tol1992MultipleDD,
  title={Multiple dopamine D4 receptor variants in the human population},
  author={Hubert H.M. Van Tol and Caren M. Wu and H C Guan and Koichi Ohara and James R. Bunzow and Olivier Civelli and James L. Kennedy and Philip Seeman and Hyman B. Niznik and Vera Jovanovic},
  journal={Nature},
  year={1992},
  volume={358},
  pages={149-152}
}
THE dopamine D4 receptor structurally and pharmacologically resembles the dopamine D2 and D3 receptors1–5. Clozapine, an atypical antipsychotic that is relatively free of the adverse effects of drug-induced parkinsonism and tardive dyskinesia6,7, binds to the D4 receptor with an affinity 10 times higher than to the D2 and D3 receptors1. This may explain clozapine's atypical properties. Here we report the existence of at least three polymorphic variations in the coding sequence of the human D4… Expand
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TLDR
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TLDR
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TLDR
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Dopamine D4 receptor variant in Africans, D4valine194glycine, is insensitive to dopamine and clozapine: report of a homozygous individual.
TLDR
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Analysis of the D4 dopamine receptor gene variant in an Italian schizophrenia kindred.
TLDR
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Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor.
TLDR
It is demonstrated that pipamperone, an antipsychotic, acts as a pharmacological chaperone and by doing so, increases the expression level of the dopamine D4 receptor. Expand
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