Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4.


The complement system is fundamental to both innate and adaptive immunity and can be initiated via the classical, lectin or alternative pathways. Cleavage of C4 by MASP-2, the initiating protease of the lectin pathway, is a crucial event in the activation of this pathway, preceding the eventual formation of the C3 convertase (C4bC2a) complex on the pathogen… (More)
DOI: 10.1016/j.molimm.2011.10.006