Multiple distinct small RNAs originate from the same microRNA precursors

  title={Multiple distinct small RNAs originate from the same microRNA precursors},
  author={Weixiong Zhang and Shang Gao and Xuefeng Zhou and Jing Xia and Padmanabhan Chellappan and Xiang Zhou and Xiaoming Zhang and Hailing Jin},
  booktitle={Genome Biology},
MicroRNAs (miRNAs), which originate from precursor transcripts with stem-loop structures, are essential gene expression regulators in eukaryotes. We report 19 miRNA precursors in Arabidopsis that can yield multiple distinct miRNA-like RNAs in addition to miRNAs and miRNA*s. These miRNA precursor-derived miRNA-like RNAs are often arranged in phase and form duplexes with an approximately two-nucleotide 3'-end overhang. Their production depends on the same biogenesis pathway as their sibling… CONTINUE READING


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