Multiple display of catalytic modules on a protein scaffold: nano-fabrication of enzyme particles.

@article{Heyman2007MultipleDO,
  title={Multiple display of catalytic modules on a protein scaffold: nano-fabrication of enzyme particles.},
  author={Arnon Heyman and Yoav Barak and Jonathan Caspi and David B. Wilson and Arie Altman and Edward A Bayer and Oded Shoseyov},
  journal={Journal of biotechnology},
  year={2007},
  volume={131 4},
  pages={433-9}
}
Self assembly is a prerequisite for fabricating nanoscale structures. Here we present a new fusion protein based on the stress-responsive homo-oligomeric protein, SP1. This ring-shaped protein is a highly stable homododecamer, which can be potentially utilized to self-assemble different modules and enzymes in a predicted and oriented manner. For that purpose, a cohesin module (a component of the bacterial cellulosome) was selected, its gene fused in-frame to SP1, and the fusion protein was… CONTINUE READING

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