Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes.

@article{Wilson2000MultipleDI,
  title={Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes.},
  author={Sandy Wilson and Sally C. Kent and Heidi F. Horton and Andrew A. Hill and Paul L Bollyky and David A. Hafler and Jack Leonard Strominger and Michael C. Byrne},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 13},
  pages={
          7411-6
        }
}
Quantitative and qualitative defects in CD1d-restricted T cells have been demonstrated in human and murine autoimmune diseases. To investigate the transcriptional consequences of T cell receptor activation in human Valpha24JalphaQ T cell clones, DNA microarrays were used to quantitate changes in mRNA levels after anti-CD3 stimulation of clones derived from identical twins discordant for type 1 diabetes and IL-4 secretion. Activation resulted in significant modulation of 226 transcripts in the… CONTINUE READING

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