Multiple deleted regions on the long arm of chromosome 6 in astrocytic tumours

  title={Multiple deleted regions on the long arm of chromosome 6 in astrocytic tumours},
  author={Ayako Miyakawa and Koichi Ichimura and Esther E. Schmidt and Shohreh Varmeh-Ziaie and Vincent Peter Collins},
  journal={British Journal of Cancer},
  pages={543 - 549}
Chromosome 6 deletions are common in human neoplasms including gliomas. In order to study the frequency and identify commonly deleted regions of chromosome 6 in astrocytomas, 159 tumours (106 glioblastomas, 39 anaplastic astrocytomas and 14 astrocytomas malignancy grade II) were analysed using 31 microsatellite markers that span the chromosome. Ninety-five per cent of cases with allelic losses had losses affecting 6q. Allelic losses were infrequent in astrocytomas malignancy grade II (14%) but… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 17 extracted citations


Publications referenced by this paper.
Showing 1-10 of 30 references

Mutational profile of thePTENgene in primary human astrocytic tumours an cultivated xenografts

  • J Br
  • J Neuropathol Exp Neurol
  • 1999

Infrequent methylation of CDKN 2 A ( MTS 1 / p 16 ) and rare mutation of both CDKN 2 A and CDKN 2 B ( MTS 2 / p 15 ) in primary astrocytic tumours

  • EE Schmidt, K Ichimura, HM Goike, A Moshret, L Liu, VP Collins
  • Br J Cancer
  • 1997
2 Excerpts

Similar Papers

Loading similar papers…