Multiple daily amphetamine administration: behavioral and neurochemical alterations.

@article{Segal1980MultipleDA,
  title={Multiple daily amphetamine administration: behavioral and neurochemical alterations.},
  author={D. S. Segal and S B Weinberger and Jc L H Cahill and S J McCunney},
  journal={Science},
  year={1980},
  volume={207 4433},
  pages={904-7}
}
In rats, multiple daily amphetamine injections (2.5 milligrams per kilogram of body weight, injected subcutaneously every 4 hours for 5 days) resulted in a progressive augmentation in response, characterized by a more rapid onset and an increased magnitude of stereotypy. By contrast, offset times of both the stereotypy and the poststereotypy hyperactivity periods were markedly shortened. When the animals were retested with the same dose of amphetamine 8 days after the long-term treatment was… CONTINUE READING
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