Multiple cytokines regulate the expression of extracellular superoxide dismutase in human vascular smooth muscle cells.

@article{Strlin2000MultipleCR,
  title={Multiple cytokines regulate the expression of extracellular superoxide dismutase in human vascular smooth muscle cells.},
  author={Pontus Str{\aa}lin and Stefan L Marklund},
  journal={Atherosclerosis},
  year={2000},
  volume={151 2},
  pages={433-41}
}
Oxygen free radicals as well as immunological reactions have been suggested to play important roles in atherogenesis and other pathological processes of the blood vessel wall. We have previously shown that the vascular wall contains exceptionally large amounts of extracellular superoxide dismutase (EC-SOD) and that the enzyme is produced and secreted to the extracellular space by the smooth muscle cells. In this work, we studied the influence of inflammatory cytokines on vascular smooth muscle… CONTINUE READING
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