Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation.

@article{Hitzemann2002MultipleCM,
  title={Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation.},
  author={Robert J. Hitzemann and Barry Malmanger and Staci Cooper and Shannon Coulombe and Cheryl J. Reed and Kristin Demarest and Jay Koyner and Laura J. Cipp and Jonathan Flint and Christopher David Talbot and Brooks L. S. Rademacher and Matthew T. Reilly and James A. Mccaughran},
  journal={Genes, brain, and behavior},
  year={2002},
  volume={1 4},
  pages={
          214-22
        }
}
This study examines the use of multiple cross mapping (MCM) to reduce the interval for an ethanol response QTL on mouse chromosome 1. The phenotype is the acute locomotor response to a 1.5-g/kg i.p. dose of ethanol. The MCM panel consisted of the six unique intercrosses that can be obtained from the C57BL/6J (B6), DBA/2J (D2), BALB/cJ (C) and LP/J (LP) inbred mouse strains (N > or = 600/cross). Ethanol response QTL were detected only with the B6xD2 and B6xC intercrosses. For both crosses, the… CONTINUE READING
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