Multiple cognitive deficits during the transition to Alzheimer's disease

@article{Bckman2004MultipleCD,
  title={Multiple cognitive deficits during the transition to Alzheimer's disease},
  author={Lars B{\"a}ckman and S. Jones and A K Berger and Erika J. Laukka and Brent J. Small},
  journal={Journal of Internal Medicine},
  year={2004},
  volume={256}
}
The literature on cognitive markers in preclinical AD is reviewed. The findings demonstrate that impairment in multiple cognitive domains is typically observed several years before clinical diagnosis. Measures of executive functioning, episodic memory and perceptual speed appear to be most effective at identifying at‐risk individuals. The fact that these cognitive domains are most implicated in normal cognitive aging suggests that the cognitive deficit observed preclinically is not… 
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285 Citations
Highly Influential Citations
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285 Citations

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  • 2012
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To examine the preclinical onset of cognitive decline, subjects were aligned at the time of initial AD diagnosis and the cognitive course preceding diagnosis found that declines in performance on tests of episodic memory accelerated 7 years before diagnosis.
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