Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer.

@article{Park1999MultipleCA,
  title={Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer.},
  author={In won Park and Ignacio Wistuba and Anirban Maitra and Sara Milchgrub and Arvind K. Virmani and John D. Minna and Adi F. Gazdar},
  journal={Journal of the National Cancer Institute},
  year={1999},
  volume={91 21},
  pages={1863-8}
}
BACKGROUND Several molecular changes, including loss of heterozygosity (i.e., deletion of one copy of allelic DNA sequences) and alterations in microsatellite DNA, have been detected early in the pathogenesis of lung cancer, even in histologically normal epithelium. In the bronchial epithelium of patients with lung cancer, we have determined the frequency, size, and patterns of molecularly abnormal clonal patches. METHODS We studied formalin-fixed, paraffin-embedded samples from 16 surgically… CONTINUE READING

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